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The Early Renaissance, throughout the 15th century, was a period of great creative and intellectual art formations. Renaissance artists studied the natural world in order to firm their understanding of such subjects as anatomy and perspective. The great artists of the early renaissance era were Sandro Botticelli, Domenico Ghirlandaio, Paolo Uccello and Piero della Francesca. High Renaissance, the time just before the 16th century is notable for three of the greatest artists in history, Michelangelo, Raphael ,and Leonardo da Vinci.